Histidine is called a semi-essential amino acid (protein building block) because adults generally produce adequate amounts but infants and children may not. Histidine is a precursor of histamine, a compound released by immune system cells during an allergic reaction.

Infants can obtain histidine from breast and formula milk, whilst pork, soybeans, cheese, baked beans,

beef, kidney beans, turkey, dairy products, chicken, mung beans and chickpeas are good dietary sources of histidine.

What it does

  1. Anti-Arthritic: Levels of histidine have been shown to be depleted both in the blood serum and joint synovial fluid of rheumatoid arthritis (RA) sufferers, which suggests that histidine supplementation may be of benefit in RA. Some studies have shown benefits of histidine supplementation in strength and mobility in RA sufferers.
  2. Heavy Metal Protection: L-Histidine is needed along with L-cysteine to protect the body agains toxic metals such as mercury, lead, cadmium, and threatening excesses of essential minerals zinc and copper.
  3. Sexual Function: Histidine is needed to manufacture histamine, an essential compound for achieving sexual climax in both men and women. Men and women having difficulties achieving orgasms may be helped by histidine supplementation, as this may result in increased histamine levels in the sexual tract, which in turn may make orgasm and ejaculation easier. An additional pro-sexual effect of histidine may lay in its vasodilating effect, thus making blood flow to the sex organs easier.

Potential Uses

Circulatory disorders Detox of heavy metals Rheumatoid arthritis
Impotence Frigidity


Should be avoided by people with elevated levels of histidine or histamine such as those with manic depression, schizophrenia and chronic allergies.

Do not use in pregnancy or when breastfeeding.

As histamine triggers gastric secretions, histidine should not be taken by anyone with a peptic ulcer.

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