DLPA is a combination of the amino acid L-Phenylalanine and its mirror image molecule, D-Phenylalanine. Whilst D forms of amino acids do not normally act in the body, D-Phenylalanine is a rare exception.
DLPA is thought to prolong the life of endorphins, our “feel good” hormones which are released during exercise and are pain relieving.
What is DLPA Good For?
- Anti-Depressant: Phenylalanine is a precursor to the mood elevating compound dopamine, which is found to be low in some depressed patients. It also enhances other mood enhancing chemicals such as PEA and endorphins.
- Pain Reliever: DLPA appears to prevent the actions of a pain-inducing protein called enkephalinase, while also elevating morphine-like endorphins in the brain.
- Mental Alertness:
Aside from dopamine, DLPA converts into other stimulatory brain chemicals, such as noradrenaline (norepinephrine), which may ultimately enhance mental alertness. - Appetite Control:
CCK (cholecystokinin) is an intestinal hormone that signals the brain to feel satisfied when enough food is consumed. Phenylalanine governs the release of CCK and as such, is thought to act as an appetite suppressant. - Premenstrual Syndrome:
Phenylalanine has been shown to alleviate several psychological and emotional symptoms associated with PMS.
Potential Uses
| Depression | Mental fatigue | Migraines |
| Appetite control | PMS | Fibromyalgia |
| Back ache | Lumbago | Toothache |
| Osteoarthritis | Rheumatoid arthritis | Menstrual cramps |
Food sources of DLPA include
soybeans, cottage cheese, fish, meat, poultry, almonds, brazil nuts, pecans, pumpkin, sesame seeds, chickpeas and lentils.
DLPA, or DL-Phenylalanine, is a dietary supplement that combines two forms of the amino acid phenylalanine: D-phenylalanine (DPA) and L-phenylalanine. This combination is believed to have various health benefits, particularly related to mood enhancement, pain relief, and cognitive function.
Health Benefits
Pain Relief:
DLPA may help in managing chronic pain. DPA is thought to inhibit an enzyme that breaks down endorphins, which are natural pain-relieving chemicals in the body. Some studies suggest that DPA can reduce chronic pain associated with conditions like osteoarthritis and may enhance the effects of acupuncture in patients with low back pain. However, results from clinical trials have been mixed; while some show efficacy in pain relief, others report no significant difference from placebo.
Mood Enhancement:
The supplement is also associated with promoting a healthy mood and cognitive function. By supporting the production of neurotransmitters that elevate mood, DLPA may contribute to a sense of well-being. It is often recommended for those experiencing stress or withdrawal symptoms, as it has shown promise in reducing these effects in alcoholics when combined with other amino acids.
Cognitive Function:
L-phenylalanine, one of the components of DLPA, serves as a precursor to neurotransmitters like dopamine and norepinephrine, which are crucial for maintaining alertness and cognitive function.
Recommended Dosage
The typical dosage for DLPA ranges from 1,500 mg to 2,500 mg per day, depending on individual needs and specific health goals. It is often taken in divided doses throughout the day.
Forms and Availability
DLPA supplements are available in various forms including capsules and tablets. Common dosages include:
- 500 mg per capsule (e.g., Solgar DLPA)
- 750 mg per tablet (e.g., Source Naturals DLPA)
- 1000 mg options are also available for those requiring higher doses
Top IHerb DLPA Supplement
Solgar DLPA, DL-Phenylalanine, Free Form
Rating: 4.7
Reviews: 340
Price: $21.23
Description:
Since 1947, Solgar has been dedicated to providing the highest quality nutritional supplements. Their DLPA (DL-Phenylalanine) offers a unique blend of both the D and L forms of the amino acid phenylalanine. This powerful formulation may help reduce the activity of the enzyme enkephalinase in the central nervous system, promoting the preservation of feel-good hormones like endorphins and enkephalins.
Each serving provides Free Form DLPA, ensuring optimal absorption and assimilation. It’s also non-GMO, certified gluten-free, and suitable for vegans, making it an excellent choice for a wide range of dietary needs.
Ingredients:
Free From:
Gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavors, sweeteners, preservatives, and color.
Suggested Use:
As a dietary supplement for adults, take one (1) vegetable capsule two times daily, preferably with meals, or as directed by a healthcare practitioner.
2. Life Extension D, L-Phenylalanine, 500 mg
Rating: 4.7
Reviews: 761
Price: $14.25
Description:
- Gluten Free
- Non-GMO
- LE Certified
- Enhances Mood
- Dietary Supplement
D, L-Phenylalanine is an essential amino acid that your body cannot produce in sufficient amounts, making it necessary to obtain from external sources. Once consumed, it’s converted into L-tyrosine in the liver, which is then transformed into key neurotransmitters like dopamine, norepinephrine, and epinephrine (adrenaline). These neurotransmitters are vital for maintaining brain health and cognitive function.
Benefits of D, L-Phenylalanine:
- Supports the production of L-tyrosine, crucial for dopamine and norepinephrine synthesis
- Promotes healthy mood and sleep patterns
- Supports healthy cognitive function
- Provides protection for brain cells
Suggested Use:
Take one (1) capsule daily on an empty stomach in the morning, or as recommended by a healthcare practitioner. For optimal benefits, it’s best taken with co-factors such as vitamins B6 and C.
Other Ingredients:
Vegetable cellulose (capsule), vegetable stearate, microcrystalline cellulose.
3. Carlson DLPA, DL-Phenylalanine, 500 mg
Rating: 4.8
Reviews: 48
Price: $12.27
Description:
Carlson DLPA (DL-Phenylalanine) provides a high-quality source of this essential amino acid in easy-to-take capsules. Known for its mood-enhancing properties, DLPA may help support brain health by increasing levels of important neurotransmitters.
Benefits of Carlson DLPA:
- Supports mood and emotional well-being
- Aids in the production of neurotransmitters for better cognitive function
- Promotes overall brain health
Suggested Use:
As a dietary supplement, take one capsule daily, or as directed by a healthcare practitioner.
Considerations
While DLPA is generally considered safe for most people, it should be used cautiously by individuals taking medications such as L-dopa for Parkinson’s disease, as it may interfere with its transport to the brain. Consulting a healthcare provider before starting any new supplement regimen is advisable.In summary, DLPA holds potential benefits for pain management and mood enhancement but should be approached with careful consideration regarding dosage and individual health conditions.
How does DLPA compare to other pain relief supplements
DLPA (DL-Phenylalanine) is a unique supplement that combines two forms of the amino acid phenylalanine, providing potential benefits for pain relief and mood enhancement. When comparing DLPA to other pain relief supplements, several key factors emerge:
Mechanism of Action
- DLPA: It works by inhibiting the enzymes that break down endorphins, the body’s natural painkillers. This prolongs their action, potentially offering relief from chronic pain conditions such as arthritis and fibromyalgia. D-phenylalanine (DPA), a component of DLPA, has been shown to reduce pain by blocking the breakdown of endorphins and enkephalins.
- Other Pain Relief Supplements:
- Turmeric/Curcumin: Known for its anti-inflammatory properties, turmeric works primarily through its active compound curcumin, which inhibits inflammatory pathways.
- Glucosamine and Chondroitin: Commonly used for joint health, these supplements aim to support cartilage repair and reduce inflammation but do not directly affect pain pathways like DLPA.
- Omega-3 Fatty Acids: These have anti-inflammatory effects and can help with joint pain but work differently than DLPA’s endorphin-enhancing mechanism.
Efficacy
- DLPA: Studies indicate that DLPA can be effective for chronic pain management, with reports of significant relief in some patients. However, results are mixed; some clinical trials show no significant difference from placebo. It is particularly noted for its effectiveness in chronic conditions rather than acute pain.
- Other Supplements:
- Turmeric/Curcumin: Research supports its efficacy in reducing pain and inflammation, particularly in osteoarthritis and rheumatoid arthritis.
- Glucosamine and Chondroitin: Some studies suggest these can help with knee osteoarthritis but results vary widely.
- Omega-3 Fatty Acids: Evidence supports their role in reducing joint pain and stiffness in inflammatory conditions.
Side Effects and Interactions
- DLPA: Generally considered safe, it can interact with certain medications (especially those affecting dopamine levels) and may cause overstimulation in some individuals. It is non-addictive and can be taken alongside prescription pain relievers for enhanced effects.
- Other Supplements:
- Turmeric/Curcumin: Generally safe but may cause gastrointestinal issues in some individuals.
- Glucosamine and Chondroitin: Can cause mild digestive upset; caution is advised for those with shellfish allergies.
- Omega-3 Fatty Acids: May increase bleeding risk if taken with anticoagulants.
How does DLPA affect endorphin levels in the body
DLPA (DL-Phenylalanine) significantly affects endorphin levels in the body through its unique mechanism of action, primarily involving the inhibition of enzymes that degrade these natural pain-relieving substances.
Mechanism of Action
- Inhibition of Enzymes: DLPA contains D-phenylalanine (DPA), which acts as an inhibitor of enzymes such as endorphinase and enkephalinase. These enzymes are responsible for breaking down endorphins and enkephalins, which are crucial for pain relief and mood regulation. By slowing the action of these enzymes, DLPA effectively increases the availability and longevity of endorphins in the body.
- Impact on Endorphin Levels: Research has shown that administration of DPA leads to increased levels of endorphins in specific brain regions, such as the pituitary gland and striatum. This increase can enhance the analgesic effects and improve mood, particularly in individuals with chronic pain or addiction issues. In clinical settings, patients have reported significant pain relief within minutes to hours after taking DPA, highlighting its rapid action.
Clinical Evidence
- Pain Management: Studies indicate that DLPA can reduce pain by preserving endorphin levels. For instance, a study found that chronic pain patients experienced substantial relief after treatment with DPA, with many reporting good to complete relief within a few weeks. The mechanism is believed to be due to the enhanced activity of endorphins, which bind to opioid receptors in the brain, influencing pain perception.
- Mood Enhancement: Beyond pain relief, increased endorphin levels can also contribute to improved mood and well-being. This is particularly relevant for individuals suffering from conditions like depression or anxiety, where endorphin dysregulation may play a role.
DLPA enhances endorphin levels by inhibiting their breakdown through enzyme action. This leads to increased analgesic effects and improved mood states, making it a valuable supplement for managing chronic pain and emotional well-being. However, as with any supplement, individual responses may vary, and it is advisable to consult healthcare professionals before starting DLPA for therapeutic purposes.
Cautions
Do not use in pregnancy or when breastfeeding.
Combined use with antipsychotic drugs may increase the risk of developing tardive dyskinesia.
Phenylalanine may cause hypertension if taken with MAOI medication.
PKU sufferers should avoid DLPA as they are not able to absorb it.
Conclusion
DLPA presents a unique approach to pain relief by enhancing the body’s natural analgesic mechanisms through endorphin preservation. While it may offer benefits similar to other supplements, particularly for chronic pain, its effectiveness can vary among individuals. Other supplements like turmeric or glucosamine target different pathways and may be more effective for inflammation-related pain. As always, consulting a healthcare provider before starting any new supplement regimen is advisable to tailor choices to individual health needs.
