Glucosamine is an important building block made by the body to manufacture specialized molecules called glycosaminoglycans, which are found in healthy joint tissue and cartilage. As we get older, we get less effecient at making glucosamine and demand in the joints outstrips supply leading to joints being progressively worn away.
Glucosamine sulphate, derived from the shells of crustaceans such as lobster and crab, is used to make up the deficiency in production by the body. Vegetarian sources of glucosamine are also available for anyone with a shellfish allergy.
What it does
- Joint Protection and Repair: Glucosamine is utilised by the joints to repair, strengthen and improve the integrity of the cartilage, in addition to improving the viscosity of the synovial fluid in joints.
- Connective Tissue Injury: Damage to cartilage and soft tissues in and around joints can also be due to sports injury, heavy lifting, etc. Chondrocytes in the joint use glucosamine to produce glycosaminoglycans (GAGs) and glycoproteins, which repair the joint and improve mobility by strengthening the cartilage and connective tissues. These compounds are also important in the repair of bone tissue in the case of fracture or age-related bone loss.
- Intestinal Permeability: Glycosaminoglycans and glycoproteins, an integral part of cell membranes and connective tissue can help stabilise the tissue lining the gut. Supplementing glucosamine can be helpful where there is intestinal damage due to conditions such as chronic candidiasis, alcoholism or inflammatory bowel disease.
- Vascular Health: Provides support and elasticity to artery walls as well as protection and aid to repair.
Potential Uses
| Ankylosing spondylitis | Osteo arthritis | Cardiovascular health |
| Varicose veins | Sports injuries |
Joint problems |
Chondroitin is often used alongside glucosamine to support its action.
Cautions
Although interactions are rare, diabetics should be monitored regularly as a precaution, if they intend to use glucosamine.
If you are allergic to shellfish, make sure that you take a vegetarian form of glucosamine.
At the time of writing there were no well known negative drug interactions with glucosamine.
Generally, there are no side effects or contra-indications from using glucosamine.
FAQ`s about Glucosamine
What does glucosamine do for your body?
Glucosamine helps support joint health by promoting the repair of cartilage and maintaining its structure. It is commonly used to relieve symptoms of osteoarthritis, such as joint pain and stiffness.
Why do doctors not recommend glucosamine?
Some doctors hesitate to recommend glucosamine because scientific studies show mixed results regarding its effectiveness. Additionally, it is not regulated as strictly as medications, and concerns exist about its quality and purity.
What are side effects of glucosamine?
Common side effects may include nausea, heartburn, diarrhea, and drowsiness. Rarely, some people experience allergic reactions, especially those allergic to shellfish, since glucosamine is often derived from shellfish shells.
Why should people over 60 not take glucosamine?
People over 60 are not universally advised to avoid glucosamine, but caution is recommended due to potential interactions with other medications and the presence of chronic conditions. Consulting a healthcare provider is important before starting supplements at this age.
Is glucosamine an anti-inflammatory?
Glucosamine is not classified as a direct anti-inflammatory, but it may have mild anti-inflammatory effects that help reduce joint inflammation indirectly.
Is turmeric better than glucosamine?
Turmeric contains curcumin, a compound with strong anti-inflammatory properties, which can help reduce joint pain. Whether turmeric is better than glucosamine depends on the individual and condition; some may benefit more from turmeric’s anti-inflammatory effects, while others from glucosamine’s cartilage support.
Who shouldn’t take glucosamine?
People allergic to shellfish, those on blood thinners (like warfarin), or individuals with diabetes should avoid glucosamine or use it cautiously under medical supervision.
What is the best supplement for joints?
There is no one-size-fits-all, but commonly recommended joint supplements include glucosamine, chondroitin, omega-3 fatty acids, and turmeric. Effectiveness varies per individual.
Is glucosamine hard on your liver?
Glucosamine is generally considered safe for the liver when taken at recommended doses. However, those with liver disease should consult a doctor before use.
Will glucosamine raise blood pressure?
Most studies show glucosamine does not raise blood pressure, but people with hypertension should monitor their condition when starting any new supplement.
